Wayne Rooney could well be the man to set Manchester United on their way towards retaining their crown as he scores first in a 3-0 victory over QPR.

The stakes are high for both Arsenal and Manchester City but both could lose ground to their rivals as Robin van Persie scores first in a 1-1 draw.

This crunch clash will see Peter Odemwingie open the scoring for West Brom before Blackburn battle back and end up with a 2-2 draw.

Spurs’ return to form has come at a bad time for Sunderland so back Gareth Bale to open scoring in a 3-1 win for Harry Redknapp’s men.

Peter Crouch will be on hand to open the scoring as Stoke ease to a 2-0 triumph and pile more misery on Wolves boss Terry Connor.

Expect David Moyes’ Everton to come out on top in this one at Norwich with Steven Pienaar breaking the deadlock in a 2-1 victory.

Expect a jittery Liverpool side to sneak a 2-1 win against Aston Villa, with skipper Steven Gerrard opening the scoring at Anfield.

Chelsea will be too strong for Wigan with striker Fernando Torres continuing his recent upturn in fortunes with the opener in 2-0 win.

Bet on Bolton to edge a tight encounter with Ivan Klasnic nicking the only goal of the game in a narrow 1-0 victory at the Reebok.

Swansea are strong at home and despite Newcastle's recent good form, they will be undone by a Scott Sinclair penalty in a 1-0 defeat..

Manchester United hope to avoid another setback to their title hopes and Wayne Rooney could open the scoring in a 2-1 win at Blackburn.

Tottenham may be keener than Swansea as they hunt for Champions League football, so back Rafael van der Vaart to net in a 2-0 home win.

Form is temporary but class is permanent so let's go for Luis Suarez to fire Liverpool to a much-needed 2-1 victory over Newcastle.

Bolton may just be able to repeat last season’s Molineux success, with Kevin Davies fancied to fire the visitors to a 2-1 triumph.

It would be no surprise to see these teams share the spoils, with Peter Crouch getting the nod to net first for Stoke in a 1-1 draw.

The Gunners are playing with much more confidence now and will shade this 2-1, with top scorer Robin van Persie breaking the deadlock.

Black Cats have lost on last seven trips to Eastlands and Blues are fancied to cruise to 3-0 win, with Mario Balotelli netting first.

This has all the makings of an entertaining encounter that could go either way but Clint Dempsey will net first in 2-1 win for Fulham.

Everton, who have already beaten Baggies twice this term, will triumph 2-1 with Nikica Jelavic continuing his good form with opener.

Chelsea will be gunning for revenge after losing 3-1 to Villa at Stamford Bridge, so take Frank Lampard to fire the Blues to a 1-0 win.